According to the description of activities defined in the Health Care Act, the Croatian Institute of Telemedicine issues licences to practice to telemedicine centres and supervises their work and that of health care professionals. The Ordinance on the conditions, organization and manner of practising telemedicine defines basic concepts in telemedicine, the conditions for providing telemedicine services, the manner of defining a telemedicine centre network, the way of ensuring the required equipment and telecommunication lines, the relationships between participants included in telemedicine, and the manner and conditions for obtaining licences to practice as a telemedicine centre and supervision over the work of telemedicine centres and health care professionals.

In line with the Health Care Act, the activities of the Croatian Institute of Telemedicine also include the issuing of licences to practice to telemedicine centres. The records of issued/revoked licences to practice of telemedicine centres are kept in a register.